GMNN (geminin DNA replication inhibitor)

2006-10-01  

Identity

HGNC
LOCATION
6p22.3
LOCUSID
ALIAS
Gem,MGORS6
FUSION GENES

Other Information

Locus ID:

NCBI: 51053
MIM: 602842
HGNC: 17493
Ensembl: ENSG00000112312

Variants:

dbSNP: 51053
ClinVar: 51053
TCGA: ENSG00000112312
COSMIC: GMNN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112312ENST00000230056O75496
ENSG00000112312ENST00000230056A0A024QZY7
ENSG00000112312ENST00000356509O75496
ENSG00000112312ENST00000356509A0A024QZY7
ENSG00000112312ENST00000378054E2QRF9
ENSG00000112312ENST00000378059H7C608
ENSG00000112312ENST00000476555C9K0U5
ENSG00000112312ENST00000620958O75496
ENSG00000112312ENST00000620958A0A024QZY7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
CDT1 association with the CDC6:ORC:origin complexREACTOMER-HSA-68827
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152823132004Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint.116
151594172004Loss of Geminin induces rereplication in the presence of functional p53.110
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
152572902004Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.71
149932122004Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.70
194872972009Selective killing of cancer cells by suppression of geminin activity.48
169241112006A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.36
152918142004Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.35
199069942009Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.35
125519742003Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication.32

Citation

Dessen P

GMNN (geminin DNA replication inhibitor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43271/gmnn-(geminin-dna-replication-inhibitor)