HIPK1 (homeodomain interacting protein kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
Myak,Nbak2
FUSION GENES

Other Information

Locus ID:

NCBI: 204851
MIM: 608003
HGNC: 19006
Ensembl: ENSG00000163349

Variants:

dbSNP: 204851
ClinVar: 204851
TCGA: ENSG00000163349
COSMIC: HIPK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163349ENST00000340480Q86Z02
ENSG00000163349ENST00000340480A0A024R0H9
ENSG00000163349ENST00000361587H3BLW0
ENSG00000163349ENST00000369553Q86Z02
ENSG00000163349ENST00000369555Q5SQL3
ENSG00000163349ENST00000369558Q86Z02
ENSG00000163349ENST00000369559Q86Z02
ENSG00000163349ENST00000369561J3KP92
ENSG00000163349ENST00000426820Q86Z02
ENSG00000163349ENST00000503968D6RF28
ENSG00000163349ENST00000514621D6RC95
ENSG00000163349ENST00000626993Q5SQL3

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Physiological factorsREACTOMER-HSA-5578768
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384980232024Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.0
384980232024Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.0
370989802023HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.1
370989802023HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.1
360528862022Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.1
360528862022Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.1
347237812021MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.7
347856612021Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.8
347237812021MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.7
347856612021Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.8
289870302018Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.6
297934202018Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.25
289870302018Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.6
297934202018Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.25
256305572015Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).23

Citation

Dessen P

HIPK1 (homeodomain interacting protein kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43307/favicon/gene-explorer/css/card-gene.css