HIPK1 (homeodomain interacting protein kinase 1)

2006-10-01 Affiliation

Identity

HGNC

HIPK1

LOCATION

1p13.2

LOCUSID

204851

ALIAS

Myak,Nbak2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 204851
MIM: 608003
HGNC: 19006
Ensembl: ENSG00000163349

Variants:

dbSNP: 204851
ClinVar: 204851
TCGA: ENSG00000163349
COSMIC: HIPK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163349	ENST00000340480	Q86Z02
ENSG00000163349	ENST00000340480	A0A024R0H9
ENSG00000163349	ENST00000361587	H3BLW0
ENSG00000163349	ENST00000369553	Q86Z02
ENSG00000163349	ENST00000369555	Q5SQL3
ENSG00000163349	ENST00000369558	Q86Z02
ENSG00000163349	ENST00000369559	Q86Z02
ENSG00000163349	ENST00000369561	J3KP92
ENSG00000163349	ENST00000426820	Q86Z02
ENSG00000163349	ENST00000503968	D6RF28
ENSG00000163349	ENST00000514621	D6RC95
ENSG00000163349	ENST00000626993	Q5SQL3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expression	REACTOME	R-HSA-2032785
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Muscle contraction	REACTOME	R-HSA-397014
Cardiac conduction	REACTOME	R-HSA-5576891
Physiological factors	REACTOME	R-HSA-5578768
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15701637	2005	Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.	23
23565059	2013	Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.	19
24559171	2014	Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.	18
23676219	2013	HIPK1 drives p53 activation to limit colorectal cancer cell growth.	16
22173032	2012	Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.	13
25630557	2015	Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).	10
19646965	2009	HIPK1 interacts with c-Myb and modulates its activity through phosphorylation.	6
29793420	2018	Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.	3
28987030	2018	Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.	2
23071292	2012	Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues.	1

Citation

Dessen P

HIPK1 (homeodomain interacting protein kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43307/hipk1-(homeodomain-interacting-protein-kinase-1)