HIPK1 (homeodomain interacting protein kinase 1)

2006-10-01  

Identity

HGNC
HIPK1
LOCATION
1p13.2
LOCUSID
204851
ALIAS
Myak,Nbak2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 204851
MIM: 608003
HGNC: 19006
Ensembl: ENSG00000163349

Variants:

dbSNP: 204851
ClinVar: 204851
TCGA: ENSG00000163349
COSMIC: HIPK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163349ENST00000340480Q86Z02
ENSG00000163349ENST00000340480A0A024R0H9
ENSG00000163349ENST00000361587H3BLW0
ENSG00000163349ENST00000369553Q86Z02
ENSG00000163349ENST00000369555Q5SQL3
ENSG00000163349ENST00000369558Q86Z02
ENSG00000163349ENST00000369559Q86Z02
ENSG00000163349ENST00000369561J3KP92
ENSG00000163349ENST00000426820Q86Z02
ENSG00000163349ENST00000503968D6RF28
ENSG00000163349ENST00000514621D6RC95
ENSG00000163349ENST00000626993Q5SQL3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Physiological factorsREACTOMER-HSA-5578768
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384980232024Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.0
384980232024Tyr352 as a Predominant Phosphosite in the Understudied Kinase and Molecular Target, HIPK1: Implications for Cancer Therapy.0
370989802023HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.1
370989802023HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis.1
360528862022Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.1
360528862022Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.1
347237812021MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.7
347856612021Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.8
347237812021MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.7
347856612021Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.8
289870302018Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.6
297934202018Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.25
289870302018Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.6
297934202018Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.25
256305572015Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).23

Citation

Dessen P

HIPK1 (homeodomain interacting protein kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43307/js/lib/img/css/card-gene.css