MCM10 (minichromosome maintenance 10 replication initiation factor)

2006-10-01  

Identity

HGNC
LOCATION
10p13
LOCUSID
ALIAS
CNA43,DNA43,IMD80,PRO2249
FUSION GENES

Other Information

Locus ID:

NCBI: 55388
MIM: 609357
HGNC: 18043
Ensembl: ENSG00000065328

Variants:

dbSNP: 55388
ClinVar: 55388
TCGA: ENSG00000065328
COSMIC: MCM10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065328ENST00000378694Q5T670
ENSG00000065328ENST00000378714Q7L590
ENSG00000065328ENST00000479669C9J600
ENSG00000065328ENST00000484800Q7L590

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
Regulation of DNA replicationREACTOMER-HSA-69304
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177618132007Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.110
118645982002Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.91
198052162009Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.88
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
196967452009MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
176995972007Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.51
128080232003Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation.47
196087462009Physical interactions between Mcm10, DNA, and DNA polymerase alpha.27

Citation

Dessen P

MCM10 (minichromosome maintenance 10 replication initiation factor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43357/mcm10-(minichromosome-maintenance-10-replication-initiation-factor)