PASK (PAS domain containing serine/threonine kinase)

2006-10-01  

Identity

HGNC
PASK
LOCATION
2q37.3
LOCUSID
23178
ALIAS
PASKIN,STK37
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23178
MIM: 607505
HGNC: 17270
Ensembl: ENSG00000115687

Variants:

dbSNP: 23178
ClinVar: 23178
TCGA: ENSG00000115687
COSMIC: PASK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115687ENST00000234040Q96RG2
ENSG00000115687ENST00000358649Q96RG2
ENSG00000115687ENST00000403638Q96RG2
ENSG00000115687ENST00000405260Q96RG2
ENSG00000115687ENST00000415234C9J1Z3
ENSG00000115687ENST00000433589H7C0L7
ENSG00000115687ENST00000437780F8WEB4
ENSG00000115687ENST00000452907C9J4R3
ENSG00000115687ENST00000544142Q96RG2
ENSG00000115687ENST00000629419F8WEB4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
151483922004Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose.32
211813962011Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.19
209436612010Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.16
237214802013Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.16
175955312007Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.11
116889722001Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors.9
220655812011Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.9
238530952013Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.9
222196812010The role of PAS kinase in PASsing the glucose signal.8
310729272019Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.3

Citation

Dessen P

PASK (PAS domain containing serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43395/pask