CDK16 (cyclin dependent kinase 16)

2006-10-01 Affiliation

Identity

HGNC

CDK16

LOCATION

Xp11.3

LOCUSID

5127

ALIAS

PCTAIRE,PCTAIRE1,PCTGAIRE,PCTK1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5127
MIM: 311550
HGNC: 8749
Ensembl: ENSG00000102225

Variants:

dbSNP: 5127
ClinVar: 5127
TCGA: ENSG00000102225
COSMIC: CDK16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102225	ENST00000276052	Q00536
ENSG00000102225	ENST00000357227	Q00536
ENSG00000102225	ENST00000357227	A0A140VK97
ENSG00000102225	ENST00000457458	Q00536
ENSG00000102225	ENST00000457458	A0A024R183
ENSG00000102225	ENST00000462827	H0YC36
ENSG00000102225	ENST00000517426	E5RGN0
ENSG00000102225	ENST00000518022	Q00536
ENSG00000102225	ENST00000518022	A0A140VK97
ENSG00000102225	ENST00000518391	E5RJM2
ENSG00000102225	ENST00000519758	E5RIY8
ENSG00000102225	ENST00000520141	H0YC60
ENSG00000102225	ENST00000520295	E5RGV7
ENSG00000102225	ENST00000520893	E5RIU4
ENSG00000102225	ENST00000522883	E5RJQ8
ENSG00000102225	ENST00000523034	H0YBX5
ENSG00000102225	ENST00000523344	H0YAZ9
ENSG00000102225	ENST00000622098	A0A087WZU2

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22184064	2012	Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.	42
16461345	2006	Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis.	35
12154078	2002	Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.	28
25205104	2014	PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.	19
22798068	2012	Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.	16
25809707	2015	Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.	13
21335063	2011	Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development.	11
25605337	2015	PCTK1 regulates integrin-dependent spindle orientation via protein kinase A regulatory subunit KAP0 and myosin X.	10
24931367	2014	Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion.	9
30411496	2019	Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell.	8

Citation

Dessen P

CDK16 (cyclin dependent kinase 16)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43396/cdk16-(cyclin-dependent-kinase-16)