PDCD1LG2 (programmed cell death 1 ligand 2)

2006-10-01  

Identity

HGNC
LOCATION
9p24.1
LOCUSID
ALIAS
B7DC,Btdc,CD273,PD-L2,PDCD1L2,PDL2,bA574F11.2
FUSION GENES

Other Information

Locus ID:

NCBI: 80380
MIM: 605723
HGNC: 18731
Ensembl: ENSG00000197646

Variants:

dbSNP: 80380
ClinVar: 80380
TCGA: ENSG00000197646
COSMIC: PDCD1LG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197646ENST00000397747Q9BQ51

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125386842003Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.280
158377462005Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.261
284948682017Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.227
270690842016PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome.166
242707372014Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents.154
182039522008PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma.119
185663762008Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis.91
286199992017PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer.91
265413262016Prognostic significance of PD-L1 and PD-L2 in breast cancer.68
256623882015Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers.65

Citation

Dessen P

PDCD1LG2 (programmed cell death 1 ligand 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43401/pdcd1lg2-(programmed-cell-death-1-ligand-2)