PDCD6IP (programmed cell death 6 interacting protein)

2006-10-01  

Identity

HGNC
LOCATION
3p22.3
LOCUSID
ALIAS
AIP1,ALIX,DRIP4,HP95
FUSION GENES

Other Information

Locus ID:

NCBI: 10015
MIM: 608074
HGNC: 8766
Ensembl: ENSG00000170248

Variants:

dbSNP: 10015
ClinVar: 10015
TCGA: ENSG00000170248
COSMIC: PDCD6IP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170248ENST00000307296Q8WUM4
ENSG00000170248ENST00000412887F8WDK9
ENSG00000170248ENST00000413073C9IZF9
ENSG00000170248ENST00000430877F8WBR8
ENSG00000170248ENST00000435909F8WEQ7
ENSG00000170248ENST00000457054Q8WUM4
ENSG00000170248ENST00000648706A0A3B3IT07

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Uptake and function of anthrax toxinsREACTOMER-HSA-5210891

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226604132012Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.423
175565482007Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.304
178538932007Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.285
147394592004Role of LBPA and Alix in multivesicular liposome formation and endosome organization.215
173505722007Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.158
246376122014Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2.106
189485382008Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.103
242874542014ALIX and the multivesicular endosome: ALIX in Wonderland.94
185115622008ALIX-CHMP4 interactions in the human ESCRT pathway.91
186411292008Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release.91

Citation

Dessen P

PDCD6IP (programmed cell death 6 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43403/pdcd6ip-(programmed-cell-death-6-interacting-protein)