PDK1 (pyruvate dehydrogenase kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5163
MIM: 602524
HGNC: 8809
Ensembl: ENSG00000152256

Variants:

dbSNP: 5163
ClinVar: 5163
TCGA: ENSG00000152256
COSMIC: PDK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152256ENST00000282077Q15118
ENSG00000152256ENST00000392571Q15118
ENSG00000152256ENST00000410055Q15118
ENSG00000152256ENST00000416991C9IYB4
ENSG00000152256ENST00000431718F8WEJ6
ENSG00000152256ENST00000436490F8WC75
ENSG00000152256ENST00000439519C9JKT3
ENSG00000152256ENST00000443353C9JKT3

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
HIF-1 signaling pathwayKEGGhsa04066
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268
Regulation of pyruvate dehydrogenase (PDH) complexREACTOMER-HSA-204174

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24684AKT1GenePathwayassociated22336956
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
165174052006HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.1010
177854332007Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1.215
263651792015PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer.119
241235652014HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.84
176839422007Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.69
185420642008PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.52
253010522014Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.49
229481402012Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.32
291063902018Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.31
231356282013Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.28

Citation

Dessen P

PDK1 (pyruvate dehydrogenase kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43405/pdk1