INPP5J (inositol polyphosphate-5-phosphatase J)

2006-10-01 Affiliation

Identity

HGNC

INPP5J

LOCATION

22q12.2

LOCUSID

27124

ALIAS

INPP5,PIB5PA,PIPP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27124
MIM: 606481
HGNC: 8956
Ensembl: ENSG00000185133

Variants:

dbSNP: 27124
ClinVar: 27124
TCGA: ENSG00000185133
COSMIC: INPP5J

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185133	ENST00000331075	Q15735
ENSG00000185133	ENST00000400294	Q15735
ENSG00000185133	ENST00000401755	B5MBZ3
ENSG00000185133	ENST00000402238	B5MCL8
ENSG00000185133	ENST00000404390	Q15735
ENSG00000185133	ENST00000404453	B5MBZ3
ENSG00000185133	ENST00000405300	Q15735
ENSG00000185133	ENST00000412277	B4DF95
ENSG00000185133	ENST00000412985	C9K0M5
ENSG00000185133	ENST00000420017	C9J0H5
ENSG00000185133	ENST00000620191	A0A087WVS7

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Phosphatidylinositol signaling system	KEGG	ko04070
Inositol phosphate metabolism	KEGG	hsa00562
Phosphatidylinositol signaling system	KEGG	hsa04070
Metabolic pathways	KEGG	hsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	KEGG	hsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	KEGG	M00131
Metabolism	REACTOME	R-HSA-1430728
Inositol phosphate metabolism	REACTOME	R-HSA-1483249
Synthesis of IP3 and IP4 in the cytosol	REACTOME	R-HSA-1855204
Synthesis of IP2, IP, and Ins in the cytosol	REACTOME	R-HSA-1855183
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499

References

Pubmed ID	Year	Title	Citations
26267533	2015	The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.	36
25099196	2014	miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma.	24
23443536	2013	PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.	23
26282217	2015	MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.	10

Citation

Dessen P

INPP5J (inositol polyphosphate-5-phosphatase J)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43409/inpp5j