PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)

2006-10-01  

Identity

HGNC
PKMYT1
LOCATION
16p13.3
LOCUSID
9088
ALIAS
MYT1,PPP1R126
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9088
MIM: 602474
HGNC: 29650
Ensembl: ENSG00000127564

Variants:

dbSNP: 9088
ClinVar: 9088
TCGA: ENSG00000127564
COSMIC: PKMYT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127564ENST00000262300Q99640
ENSG00000127564ENST00000382240A6NHV6
ENSG00000127564ENST00000431515B4DZM6
ENSG00000127564ENST00000440027Q99640
ENSG00000127564ENST00000572059I3L1H7
ENSG00000127564ENST00000572619I3L4Y0
ENSG00000127564ENST00000573944Q99640
ENSG00000127564ENST00000574385Q99640
ENSG00000127564ENST00000574415I3L3P0
ENSG00000127564ENST00000574730Q99640
ENSG00000127564ENST00000575040I3L2S4
ENSG00000127564ENST00000575632I3L4K3
ENSG00000127564ENST00000576268I3L136

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA replication checkpointREACTOMER-HSA-69478
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Polo-like kinase mediated eventsREACTOMER-HSA-156711

References

Pubmed IDYearTitleCitations
127387812003Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.129
183787752008Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit.25
126067222003The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.24
232419492013MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells.13
164769732006Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency.10
151750242004Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation.8
286485202017PKMYT1 promoted the growth and motility of hepatocellular carcinoma cells by activating beta-catenin/TCF signaling.7
296585982018Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer.4
318370682020Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis.2
315948372019Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition.0

Citation

Dessen P

PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43411/pkmyt1