PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)

2006-10-01  

Identity

HGNC
PKMYT1
LOCATION
16p13.3
LOCUSID
9088
ALIAS
MYT1,PPP1R126
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9088
MIM: 602474
HGNC: 29650
Ensembl: ENSG00000127564

Variants:

dbSNP: 9088
ClinVar: 9088
TCGA: ENSG00000127564
COSMIC: PKMYT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127564ENST00000262300Q99640
ENSG00000127564ENST00000382240A6NHV6
ENSG00000127564ENST00000431515B4DZM6
ENSG00000127564ENST00000440027Q99640
ENSG00000127564ENST00000572059I3L1H7
ENSG00000127564ENST00000572619I3L4Y0
ENSG00000127564ENST00000573944Q99640
ENSG00000127564ENST00000574385Q99640
ENSG00000127564ENST00000574415I3L3P0
ENSG00000127564ENST00000574730Q99640
ENSG00000127564ENST00000575040I3L2S4
ENSG00000127564ENST00000575632I3L4K3
ENSG00000127564ENST00000576268I3L136

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA replication checkpointREACTOMER-HSA-69478
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Polo-like kinase mediated eventsREACTOMER-HSA-156711

References

Pubmed IDYearTitleCitations
384423722024PKMYT1 Promotes Epithelial-Mesenchymal Transition Process in Triple-Negative Breast Cancer by Activating Notch Signaling.0
384423722024PKMYT1 Promotes Epithelial-Mesenchymal Transition Process in Triple-Negative Breast Cancer by Activating Notch Signaling.0
363504962023PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity.0
365128492023Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.0
369888912023ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.2
375722182023PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors.1
363504962023PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity.0
365128492023Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.0
369888912023ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.2
375722182023PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors.1
351149892022Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.61
354442832022CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.54
355806992022KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.2
351149892022Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.61
354442832022CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.54

Citation

Dessen P

PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43411/teaching-explorer/haematological-explorer/css/template-nav.css