POLA2 (DNA polymerase alpha 2, accessory subunit)

2006-10-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 23649
HGNC: 30073
Ensembl: ENSG00000285816

Variants:

dbSNP: 23649
ClinVar: 23649
TCGA: ENSG00000285816
COSMIC: POLA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000285816ENST00000649896A0A3B3ITS5

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
DNA replicationKEGGko03030
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
DNA replicationKEGGhsa03030
Metabolic pathwaysKEGGhsa01100
DNA polymerase alpha / primase complexKEGGhsa_M00261
DNA polymerase alpha / primase complexKEGGM00261
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
Inhibition of replication initiation of damaged DNA by RB1/E2F1REACTOMER-HSA-113501
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA replication initiationREACTOMER-HSA-68952
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Processive synthesis on the lagging strandREACTOMER-HSA-69183
Removal of the Flap IntermediateREACTOMER-HSA-69166
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Telomere C-strand synthesis initiationREACTOMER-HSA-174430
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
DNA ReplicationREACTOMER-HSA-69306

References

Pubmed IDYearTitleCitations
225935762012A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.16
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
289344862017STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.12
192376062009Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.11
255216642014Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.4
281556582016Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells.4

Citation

Dessen P

POLA2 (DNA polymerase alpha 2, accessory subunit)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43415/pola2