POLN (DNA polymerase nu)

2006-10-01  

Identity

HGNC
LOCATION
4p16.3
LOCUSID
ALIAS
POL4P
FUSION GENES

Other Information

Locus ID:

NCBI: 353497
MIM: 610887
HGNC: 18870
Ensembl: ENSG00000130997

Variants:

dbSNP: 353497
ClinVar: 353497
TCGA: ENSG00000130997
COSMIC: POLN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130997ENST00000382865Q7Z5Q5
ENSG00000130997ENST00000511098H0YA88
ENSG00000130997ENST00000511885Q7Z5Q5

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
127940642003POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.45
226237722012Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.37
269035122016The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.18
230455312012Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein.8
216714772012Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations.7
293303012018Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.3
171187162007A unique error signature for human DNA polymerase nu.0
199088652009Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links.0
199959042010DNA polymerase POLN participates in cross-link repair and homologous recombination.0

Citation

Dessen P

POLN (DNA polymerase nu)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43422/poln-(dna-polymerase-nu)