PRPF4B (pre-mRNA processing factor 4B)

2006-10-01  

Identity

HGNC
PRPF4B
LOCATION
6p25.2
LOCUSID
8899
ALIAS
PR4H,PRP4,PRP4H,PRP4K,dJ1013A10.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8899
MIM: 602338
HGNC: 17346
Ensembl: ENSG00000112739

Variants:

dbSNP: 8899
ClinVar: 8899
TCGA: ENSG00000112739
COSMIC: PRPF4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112739ENST00000337659Q13523
ENSG00000112739ENST00000337659A0A024QZY5
ENSG00000112739ENST00000480058Q13523
ENSG00000112739ENST00000480058A0A024QZY5
ENSG00000112739ENST00000481109H0YDJ3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
120773422002Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.35
201189382010Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.32
236864302013Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.26
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
234666432013miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells.15
296957162018Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.9
175137572007Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.8
256026302015PRP4K is a HER2-regulated modifier of taxane sensitivity.6
256026302015PRP4K is a HER2-regulated modifier of taxane sensitivity.6
288920432018Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.5

Citation

Dessen P

PRPF4B (pre-mRNA processing factor 4B)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43431/prpf4b