RND1 (Rho family GTPase 1)

2006-10-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
ARHS,RHO6,RHOS

Other Information

Locus ID:

NCBI: 27289
MIM: 609038
HGNC: 18314
Ensembl: ENSG00000172602

Variants:

dbSNP: 27289
ClinVar: 27289
TCGA: ENSG00000172602
COSMIC: RND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172602ENST00000309739Q92730
ENSG00000172602ENST00000550607H0YHG7
ENSG00000172602ENST00000551243F8VXU4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema4D in semaphorin signalingREACTOMER-HSA-400685
Sema4D mediated inhibition of cell attachment and migrationREACTOMER-HSA-416550
Sema4D induced cell migration and growth-cone collapseREACTOMER-HSA-416572
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955

References

Pubmed IDYearTitleCitations
179165602007Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.51
255317772015The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.40
119406532002Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.31
216100702011Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs).17
189968432009Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10.15
223576152012Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation.14
236033602013Interaction characteristics of Plexin-B1 with Rho family proteins.8
277703422017Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma.5
163110492005Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.2
262504592016RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.2

Citation

Dessen P

RND1 (Rho family GTPase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43473/rnd1-(rho-family-gtpase-1)