SGK2 (serum/glucocorticoid regulated kinase 2)

2006-10-01  

Identity

HGNC
SGK2
LOCATION
20q13.12
LOCUSID
10110
ALIAS
H-SGK2,dJ138B7.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10110
MIM: 607589
HGNC: 13900
Ensembl: ENSG00000101049

Variants:

dbSNP: 10110
ClinVar: 10110
TCGA: ENSG00000101049
COSMIC: SGK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101049ENST00000341458Q9HBY8
ENSG00000101049ENST00000373077X6R8H3
ENSG00000101049ENST00000373100Q9HBY8
ENSG00000101049ENST00000412111Q5H8Y5
ENSG00000101049ENST00000423407Q9HBY8
ENSG00000101049ENST00000426287Q9HBY8
ENSG00000101049ENST00000485914A0A3B3IRL0
ENSG00000101049ENST00000496343F2Z3C8
ENSG00000101049ENST00000617268A0A0G2JNI2
ENSG00000101049ENST00000647834A0A3B3IUG0
ENSG00000101049ENST00000648083A0A3B3IRX6
ENSG00000101049ENST00000648530A0A3B3IT40

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
FoxO signaling pathwayKEGGhsa04068
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367208522023SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.4
367208522023SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.4
325650242020SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.3
328482122020Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.10
325650242020SGK2 is overexpressed in colon cancer and promotes epithelial-mesenchymal transition in colon cancer cells.3
328482122020Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.10
310021262019SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.7
310021262019SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.7
275534222017Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.4
286398962017SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.9
275534222017Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.4
286398962017SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.9
267403042016Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.15
267403042016Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.15
242040152014Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.14

Citation

Dessen P

SGK2 (serum/glucocorticoid regulated kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43489/cancer-prone-explorer/case-report-explorer/js/lib/zoomerang.js