SGK2 (serum/glucocorticoid regulated kinase 2)

2006-10-01  

Identity

HGNC
SGK2
LOCATION
20q13.12
LOCUSID
10110
ALIAS
H-SGK2,dJ138B7.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10110
MIM: 607589
HGNC: 13900
Ensembl: ENSG00000101049

Variants:

dbSNP: 10110
ClinVar: 10110
TCGA: ENSG00000101049
COSMIC: SGK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101049ENST00000341458Q9HBY8
ENSG00000101049ENST00000373077X6R8H3
ENSG00000101049ENST00000373100Q9HBY8
ENSG00000101049ENST00000412111Q5H8Y5
ENSG00000101049ENST00000423407Q9HBY8
ENSG00000101049ENST00000426287Q9HBY8
ENSG00000101049ENST00000485914A0A3B3IRL0
ENSG00000101049ENST00000496343F2Z3C8
ENSG00000101049ENST00000617268A0A0G2JNI2
ENSG00000101049ENST00000647834A0A3B3IUG0
ENSG00000101049ENST00000648083A0A3B3IRX6
ENSG00000101049ENST00000648530A0A3B3IT40

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
FoxO signaling pathwayKEGGhsa04068
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126349322003Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.16
123973882002K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.11
155782122005Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes.8
267403042016Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.8
242040152014Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.6
286398962017SGK2 promotes hepatocellular carcinoma progression and mediates GSK-3β/β-catenin signaling in HCC cells.5
205117182010The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.3
275534222017Parental origin of the deletion del(20q) in Shwachman-Diamond patients and loss of the paternally derived allele of the imprinted L3MBTL1 gene.0

Citation

Dessen P

SGK2 (serum/glucocorticoid regulated kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43489/sgk2-(serum-glucocorticoid-regulated-kinase-2)