SPAG9 (sperm associated antigen 9)

2006-10-01  

Identity

HGNC
SPAG9
LOCATION
17q21.33
LOCUSID
9043
ALIAS
CT89,HLC-6,HLC4,HLC6,JIP-4,JIP4,JLP,PHET,PIG6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9043
MIM: 605430
HGNC: 14524
Ensembl: ENSG00000008294

Variants:

dbSNP: 9043
ClinVar: 9043
TCGA: ENSG00000008294
COSMIC: SPAG9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008294ENST00000262013O60271
ENSG00000008294ENST00000357122O60271
ENSG00000008294ENST00000505279O60271
ENSG00000008294ENST00000510283O60271
ENSG00000008294ENST00000510855D6RHI8
ENSG00000008294ENST00000511795H0YBE9
ENSG00000008294ENST00000513746H0Y981
ENSG00000008294ENST00000513906H0YBS5
ENSG00000008294ENST00000618113A0A087X2D8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
189228952008Sperm-associated antigen 9 is associated with tumor growth, migration, and invasion in renal cell carcinoma.29
213563542011Sperm-associated antigen 9 is a novel biomarker for colorectal cancer and is involved in tumor growth and tumorigenicity.29
196444502009The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.26
198200192009Sperm-associated antigen 9: a novel diagnostic marker for thyroid cancer.25
156937502005Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.23
211778682011N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.19
243305812013Down regulation of SPAG9 reduces growth and invasive potential of triple-negative breast cancer cells: possible implications in targeted therapy.19
243490572013Sperm associated antigen 9 plays an important role in bladder transitional cell carcinoma.18
237116892013Clinical significance and biological roles of SPAG9 overexpression in non-small cell lung cancer.17
291469372017TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.17

Citation

Dessen P

SPAG9 (sperm associated antigen 9)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43500/spag9