STK10 (serine/threonine kinase 10)

2006-10-01 Affiliation

Identity

HGNC

STK10

LOCATION

5q35.1

LOCUSID

6793

ALIAS

LOK,PRO2729

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6793
MIM: 603919
HGNC: 11388
Ensembl: ENSG00000072786

Variants:

dbSNP: 6793
ClinVar: 6793
TCGA: ENSG00000072786
COSMIC: STK10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000072786	ENST00000176763	O94804
ENSG00000072786	ENST00000520476	H0YB71

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35501867	2022	Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia.	4
35501867	2022	Systematic analysis of prognostic significance, functional enrichment and immune implication of STK10 in acute myeloid leukemia.	4
28430576	2017	Ezrin activation by LOK phosphorylation involves a PIP(2)-dependent wedge mechanism.	26
28430576	2017	Ezrin activation by LOK phosphorylation involves a PIP(2)-dependent wedge mechanism.	26
27177495	2016	Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.	1
27177495	2016	Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.	1
23842845	2013	STK10 missense mutations associated with anti-apoptotic function.	8
23842845	2013	STK10 missense mutations associated with anti-apoptotic function.	8
23209304	2012	Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.	48
23209304	2012	Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.	48
21905501	2011	Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.	0
21905501	2011	Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population.	0
20306291	2010	A three-stage genome-wide association study of general cognitive ability: hunting the small effects.	40
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20306291	2010	A three-stage genome-wide association study of general cognitive ability: hunting the small effects.	40

Citation

Dessen P

STK10 (serine/threonine kinase 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43506/css/lib/bootstrap.min.css