STYK1 (serine/threonine/tyrosine kinase 1)

2006-10-01  

Identity

HGNC
STYK1
LOCATION
12p13.2
LOCUSID
55359
ALIAS
NOK,SuRTK106
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55359
MIM: 611433
HGNC: 18889
Ensembl: ENSG00000060140

Variants:

dbSNP: 55359
ClinVar: 55359
TCGA: ENSG00000060140
COSMIC: STYK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060140ENST00000075503Q6J9G0
ENSG00000060140ENST00000535345F5GZF6
ENSG00000060140ENST00000538867F5H366
ENSG00000060140ENST00000541561F5H4G3
ENSG00000060140ENST00000542562F5H2I9
ENSG00000060140ENST00000542924H0YGL5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124712432002The protein kinase complement of the human genome.2088
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
276282142016STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.16
258845582015Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer.11
196640422009Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.10
230105922012NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt.7
248940112014Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer.7
172988542007Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers.6
194099522009Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain mRNA in patients with acute leukemia.6
287200632017STYK1 promotes Warburg effect through PI3K/AKT signaling and predicts a poor prognosis in nasopharyngeal carcinoma.6

Citation

Dessen P

STYK1 (serine/threonine/tyrosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43519/styk1