TNKS2 (tankyrase 2)

2006-10-01  

Identity

HGNC
LOCATION
10q23.32
LOCUSID
ALIAS
ARTD6,PARP-5b,PARP-5c,PARP5B,PARP5C,TANK2,TNKL,pART6
FUSION GENES

Other Information

Locus ID:

NCBI: 80351
MIM: 607128
HGNC: 15677
Ensembl: ENSG00000107854

Variants:

dbSNP: 80351
ClinVar: 80351
TCGA: ENSG00000107854
COSMIC: TNKS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107854ENST00000371627Q9H2K2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
XAV939 inhibits tankyrase, stabilizing AXINREACTOMER-HSA-5545619
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Degradation of AXINREACTOMER-HSA-4641257
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
221530772011Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.86
217999112011Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.82
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
205498202010Telomere length and genetic analyses in population-based studies of endometrial cancer risk.46
224499782012miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells.42
262464732015Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.31
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
157952502005Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.26
287235742017Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.24
274945582016Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.22

Citation

Dessen P

TNKS2 (tankyrase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43535/tnks2