TRIB2 (tribbles pseudokinase 2)

2006-10-01  

Identity

HGNC
TRIB2
LOCATION
2p24.3
LOCUSID
28951
ALIAS
C5FW,GS3955,TRB2

Other Information

Locus ID:

NCBI: 28951
MIM: 609462
HGNC: 30809
Ensembl: ENSG00000071575

Variants:

dbSNP: 28951
ClinVar: 28951
TCGA: ENSG00000071575
COSMIC: TRIB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071575ENST00000155926Q92519
ENSG00000071575ENST00000381465F8WA18
ENSG00000071575ENST00000405331B5MCX4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448320allopurinolChemicalClinicalAnnotationassociatedPD30924126

References

Pubmed IDYearTitleCitations
383946232024TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance.0
383946232024TRIB2-Mediated Modulation of AMPK Promotes Hepatic Insulin Resistance.0
367104792023Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.1
368843492023TRIB2 safeguards naive T cell homeostasis during aging.4
370839542023Upregulation of Tribbles decreases body weight and increases sleep duration.2
382549162023Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2.0
367104792023Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population.1
368843492023TRIB2 safeguards naive T cell homeostasis during aging.4
370839542023Upregulation of Tribbles decreases body weight and increases sleep duration.2
382549162023Tribbles Genes in Gastric Cancer: A Tumor-Suppressive Role for TRIB2.0
357778102022Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.0
363326082022Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.1
357778102022Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway.0
363326082022Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.1
333867062021Tribbles homolog 2 promotes hepatic fibrosis and hepatocarcinogenesis through phosphatase 1A-Mediated stabilization of yes-associated protein.4

Citation

Dessen P

TRIB2 (tribbles pseudokinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43540/js/meetings/js/lib/popper.js