TTBK1 (tau tubulin kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
BDTK
FUSION GENES

Other Information

Locus ID:

NCBI: 84630
HGNC: 19140
Ensembl: ENSG00000146216

Variants:

dbSNP: 84630
ClinVar: 84630
TCGA: ENSG00000146216
COSMIC: TTBK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146216ENST00000259750Q5TCY1
ENSG00000146216ENST00000304139X6R456

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370598192023Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.4
370598192023Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.4
342974272021The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro-degenerative hotspot.6
342974272021The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro-degenerative hotspot.6
332288092020Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.4
332288092020Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice.4
305561602019miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease.19
305561602019miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease.19
294095262018Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.41
294095262018Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.41
246377502014The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.10
254738302014The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.61
246377502014The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.10
254738302014The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.61
230886432013Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.25

Citation

Dessen P

TTBK1 (tau tubulin kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43547/gene-fusions-explorer/favicon/js/web-card-gene.js