ZWINT (ZW10 interacting kinetochore protein)

2006-10-01  

Identity

HGNC
ZWINT
LOCATION
10q21.1
LOCUSID
11130
ALIAS
HZwint-1,KNTC2AP,SIP30,ZWINT1

Other Information

Locus ID:

NCBI: 11130
MIM: 609177
HGNC: 13195
Ensembl: ENSG00000122952

Variants:

dbSNP: 11130
ClinVar: 11130
TCGA: ENSG00000122952
COSMIC: ZWINT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122952ENST00000318387A6NH27
ENSG00000122952ENST00000361148O95229
ENSG00000122952ENST00000373944O95229
ENSG00000122952ENST00000395405O95229
ENSG00000122952ENST00000489649R4GMS7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

References

Pubmed IDYearTitleCitations
379293492023ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.1
379293492023ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.1
336071722021Genome-wide association analysis of cognitive function in Danish long-lived individuals.1
336071722021Genome-wide association analysis of cognitive function in Danish long-lived individuals.1
319451942020Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.3
323238322020ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.9
319451942020Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.3
323238322020ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.9
306439692019ZWINT is the next potential target for lung cancer therapy.17
313060992019Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.65
306439692019ZWINT is the next potential target for lung cancer therapy.17
313060992019Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.65
301984012018Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.10
301984012018Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.10
264864672015Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.30

Citation

Dessen P

ZWINT (ZW10 interacting kinetochore protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43562/teaching-explorer/css/card-gene.css