LNPEP (leucyl and cystinyl aminopeptidase)

2007-02-01  

Identity

HGNC
LOCATION
5q15
LOCUSID
ALIAS
CAP,IRAP,P-LAP,PLAP
FUSION GENES

Other Information

Locus ID:

NCBI: 4012
MIM: 151300
HGNC: 6656
Ensembl: ENSG00000113441

Variants:

dbSNP: 4012
ClinVar: 4012
TCGA: ENSG00000113441
COSMIC: LNPEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113441ENST00000231368Q9UIQ6
ENSG00000113441ENST00000395770Q9UIQ6

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Endosomal/Vacuolar pathwayREACTOMER-HSA-1236977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367169172023Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.4
367169172023Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.4
326198802020The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.0
326198802020The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.0
305814992018Differential Gene Expression Profile of Renin-Angiotensin System in the Left Atrium in Mitral Regurgitation Patients.4
305814992018Differential Gene Expression Profile of Renin-Angiotensin System in the Left Atrium in Mitral Regurgitation Patients.4
280354722017Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia.3
283282062017Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.24
280354722017Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia.3
283282062017Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.24
263668902016Vasopressinase Activity: A Potential Early Biomarker for Detecting Cardiopulmonary Bypass-Associated Acute Kidney Injury?3
275011642016Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.12
278343352016A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism.3
263668902016Vasopressinase Activity: A Potential Early Biomarker for Detecting Cardiopulmonary Bypass-Associated Acute Kidney Injury?3
275011642016Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.12

Citation

Dessen P

LNPEP (leucyl and cystinyl aminopeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43606/img/img/css/lib/dataTables.bootstrap.min.css