GEMIN4 (gem nuclear organelle associated protein 4)

2007-02-01  

Identity

HGNC
LOCATION
17p13.3
LOCUSID
ALIAS
HC56,HCAP1,HHRF-1,NEDMCR,p97

Other Information

Locus ID:

NCBI: 50628
MIM: 606969
HGNC: 15717
Ensembl: ENSG00000179409

Variants:

dbSNP: 50628
ClinVar: 50628
TCGA: ENSG00000179409
COSMIC: GEMIN4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179409ENST00000319004P57678
ENSG00000179409ENST00000437269E7EN12
ENSG00000179409ENST00000570364I3L4A4
ENSG00000179409ENST00000573482I3L399
ENSG00000179409ENST00000574958I3L1J7
ENSG00000179409ENST00000576383I3L4M4
ENSG00000179409ENST00000576778I3L2C7

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Survival motor neuron (SMN) complexKEGGhsa_M00426
Survival motor neuron (SMN) complexKEGGM00426
Gene ExpressionREACTOMER-HSA-74160
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
191389932008Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.95
163015322005Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.94
207329062010Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.50
205853412011Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.43
198519842010Genetic variation in MicroRNA genes and risk of oral premalignant lesions.39
202118032010Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.25
207219752010Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.24
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
225068922012Genetic variants in the microRNA machinery gene GEMIN4 are associated with risk of prostate cancer: a case-control study of the Chinese Han population.10

Citation

Dessen P

GEMIN4 (gem nuclear organelle associated protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43612/gemin4