ACAT2 (acetyl-CoA acetyltransferase 2)

2007-02-01  

Identity

HGNC
LOCATION
6q25.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 39
MIM: 100678
HGNC: 94
Ensembl: ENSG00000120437

Variants:

dbSNP: 39
ClinVar: 39
TCGA: ENSG00000120437
COSMIC: ACAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120437ENST00000367048Q9BWD1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Fatty acid degradationKEGGko00071
Synthesis and degradation of ketone bodiesKEGGko00072
Valine, leucine and isoleucine degradationKEGGko00280
Lysine degradationKEGGko00310
Tryptophan metabolismKEGGko00380
Pyruvate metabolismKEGGko00620
Glyoxylate and dicarboxylate metabolismKEGGko00630
Propanoate metabolismKEGGko00640
Butanoate metabolismKEGGko00650
Terpenoid backbone biosynthesisKEGGko00900
Fatty acid degradationKEGGhsa00071
Synthesis and degradation of ketone bodiesKEGGhsa00072
Valine, leucine and isoleucine degradationKEGGhsa00280
Lysine degradationKEGGhsa00310
Tryptophan metabolismKEGGhsa00380
Pyruvate metabolismKEGGhsa00620
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Propanoate metabolismKEGGhsa00640
Butanoate metabolismKEGGhsa00650
Terpenoid backbone biosynthesisKEGGhsa00900
Metabolic pathwaysKEGGhsa01100
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
C5 isoprenoid biosynthesis, mevalonate pathwayKEGGhsa_M00095
C5 isoprenoid biosynthesis, mevalonate pathwayKEGGM00095
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Cholesterol biosynthesisREACTOMER-HSA-191273

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340364832021Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2.13
340364832021Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2.13
276881512016Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors.1
276881512016Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors.1
250428032014Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.58
250428032014Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.58
219874872012Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway.56
219874872012Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway.56
201675772010Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.21
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
201675772010Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.21
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
189961022009Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.13

Citation

Dessen P

ACAT2 (acetyl-CoA acetyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43642/favicon/js/lib/zoomerang.js