UNC5A (unc-5 netrin receptor A)

2007-02-01  

Identity

HGNC
UNC5A
LOCATION
5q35.2
LOCUSID
90249
ALIAS
UNC5H1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90249
MIM: 607869
HGNC: 12567
Ensembl: ENSG00000113763

Variants:

dbSNP: 90249
ClinVar: 90249
TCGA: ENSG00000113763
COSMIC: UNC5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113763ENST00000329542Q6ZN44
ENSG00000113763ENST00000509580H0Y8R2
ENSG00000113763ENST00000513890H0Y9G2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

References

Pubmed IDYearTitleCitations
292776142018Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.3
297202152018Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.11
292776142018Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.3
297202152018Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.11
287103822017Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.11
287831792017Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus.5
287103822017Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.11
287831792017Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus.5
246762802014The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis.4
247375862014DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.9
246762802014The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis.4
247375862014DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.9
203728002010Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203728002010Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.18

Citation

Dessen P

UNC5A (unc-5 netrin receptor A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43649/css/lib/cancer-prone-explorer/js/template.js