KIR2DL1 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1)

2007-02-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD158A,KIR-K64,KIR221,KIR2DL3,NKAT,NKAT-1,NKAT1,p58.1

Other Information

Locus ID:

NCBI: 3802
MIM: 604936
HGNC: 6329
Ensembl: ENSG00000125498

Variants:

dbSNP: 3802
ClinVar: 3802
TCGA: ENSG00000125498
COSMIC: KIR2DL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125498ENST00000291633P43626
ENSG00000125498ENST00000336077Q6H2H3

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Graft-versus-host diseaseKEGGko05332
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Graft-versus-host diseaseKEGGhsa05332
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
189459622009Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.166
161413292005Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.118
209352242010Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.80
199342972009KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.50
158791582005Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.46
198286942009Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.43
153105282004Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.38
128472622003Enhanced recognition of human NK receptors after influenza virus infection.35
208784002010Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.32
198465352010Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.31

Citation

Dessen P

KIR2DL1 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43665/kir2dl1