RYBP (RING1 and YY1 binding protein)

2007-02-01  

Identity

HGNC
RYBP
LOCATION
3p13
LOCUSID
23429
ALIAS
AAP1,APAP-1,DEDAF,YEAF1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23429
MIM: 607535
HGNC: 10480
Ensembl: ENSG00000163602

Variants:

dbSNP: 23429
ClinVar: 23429
TCGA: ENSG00000163602
COSMIC: RYBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163602ENST00000477973Q8N488

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124114952002Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.96
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
146914602004TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.33
190987112009RYBP stabilizes p53 by modulating MDM2.28
253440992014RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo.21
147651352004Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing.19
227239752012Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.17
119534392002YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.16
261046822015YY1 regulates melanoma tumorigenesis through a miR-9 ~ RYBP axis.11
185511462008Adenoviral-mediated Rybp expression promotes tumor cell-specific apoptosis.10

Citation

Dessen P

RYBP (RING1 and YY1 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43694/rybp