RBM3 (RNA binding motif protein 3)

2007-02-01  

Identity

HGNC
RBM3
LOCATION
Xp11.23
LOCUSID
5935
ALIAS
IS1-RNPL,RNPL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5935
MIM: 300027
HGNC: 9900
Ensembl: ENSG00000102317

Variants:

dbSNP: 5935
ClinVar: 5935
TCGA: ENSG00000102317
COSMIC: RBM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102317ENST00000354480Q9H5V0
ENSG00000102317ENST00000376755P98179
ENSG00000102317ENST00000376755A0A024QYX3
ENSG00000102317ENST00000376759P98179
ENSG00000102317ENST00000376759A0A024QYX3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
150752392004Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.79
184275442008Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe.47
207271702010Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer.40
197348502009Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.37
192779902009Down-regulating cold shock protein genes impairs cancer cell survival and enhances chemosensitivity.30
197706902010The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death.30
217774692011Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malmö Diet and Cancer Study.28
219568992011High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer.25
228053202012High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma.22
219555822011High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.21

Citation

Dessen P

RBM3 (RNA binding motif protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43710/rbm3