UCN (urocortin)

2007-02-01  

Identity

HGNC
UCN
LOCATION
2p23.3
LOCUSID
7349
ALIAS
UI,UROC

Other Information

Locus ID:

NCBI: 7349
MIM: 600945
HGNC: 12516
Ensembl: ENSG00000163794

Variants:

dbSNP: 7349
ClinVar: 7349
TCGA: ENSG00000163794
COSMIC: UCN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163794ENST00000296099P55089

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352767882022Urocortin Neuropeptide Levels Are Impaired in the PBMCs of Overweight Children.0
352767882022Urocortin Neuropeptide Levels Are Impaired in the PBMCs of Overweight Children.0
324520552020Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.22
324520552020Identification of a four immune-related genes signature based on an immunogenomic landscape analysis of clear cell renal cell carcinoma.22
282280902018Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?3
289257542018Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women.7
282280902018Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?3
289257542018Plasma urocortin-1 as a preoperative marker of endometriosis in symptomatic women.7
286985542017Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1.18
286985542017Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1.18
270455502016MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression.14
275674272016Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions.10
270455502016MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression.14
275674272016Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions.10
252395072015Secretion of urocortin I by human glioblastoma cell lines, possibly via the constitutive pathway.1

Citation

Dessen P

UCN (urocortin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43729/tumors-explorer/js/web-card-gene.js