GNLY (granulysin)

2007-02-01  

Identity

HGNC
GNLY
LOCATION
2p11.2
LOCUSID
10578
ALIAS
D2S69E,LAG-2,LAG2,NKG5,TLA519
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10578
MIM: 188855
HGNC: 4414
Ensembl: ENSG00000115523

Variants:

dbSNP: 10578
ClinVar: 10578
TCGA: ENSG00000115523
COSMIC: GNLY

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115523ENST00000263863P22749
ENSG00000115523ENST00000409696P22749
ENSG00000115523ENST00000524600B4E3H9
ENSG00000115523ENST00000526018H0YDW8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190299832008Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis.111
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
126265732003Human NKT cells express granulysin and exhibit antimycobacterial activity.49
249061492014Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.49
267525172016Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.47
220459852011Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.42
124881002003Granulysin crystal structure and a structure-derived lytic mechanism.41
124219592002CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15.39
114186702001A distinct pathway of cell-mediated apoptosis initiated by granulysin.38
206602892010Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin.34

Citation

Dessen P

GNLY (granulysin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43730/gnly