IRF7 (interferon regulatory factor 7)

2007-02-01 Affiliation

Identity

HGNC

IRF7

LOCATION

11p15.5

LOCUSID

3665

ALIAS

IMD39,IRF-7,IRF-7H,IRF7A,IRF7B,IRF7C,IRF7H

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3665
MIM: 605047
HGNC: 6122
Ensembl: ENSG00000185507

Variants:

dbSNP: 3665
ClinVar: 3665
TCGA: ENSG00000185507
COSMIC: IRF7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185507	ENST00000330243	Q92985
ENSG00000185507	ENST00000348655	Q92985
ENSG00000185507	ENST00000348655	A0A024RCA2
ENSG00000185507	ENST00000397566	Q92985
ENSG00000185507	ENST00000397570	M9RSF4
ENSG00000185507	ENST00000469048	Q92985
ENSG00000185507	ENST00000525445	Q92985
ENSG00000185507	ENST00000528413	A0A3B3ITQ5
ENSG00000185507	ENST00000532326	E9PIA7
ENSG00000185507	ENST00000532788	E9PR03
ENSG00000185507	ENST00000533182	Q92985
ENSG00000185507	ENST00000533190	E9PQ11
ENSG00000185507	ENST00000647801	A0A3B3ISS4
ENSG00000185507	ENST00000649187	A0A3B3ISC0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Toll-like receptor signaling pathway	KEGG	hsa04620
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Hepatitis B	KEGG	hsa05161
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	REACTOME	R-HSA-936964
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	REACTOME	R-HSA-975110
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF3-dependent IRF activation pathway	REACTOME	R-HSA-918233
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	REACTOME	R-HSA-3134963
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Interferon gamma signaling	REACTOME	R-HSA-877300
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164722208	MAVS	Gene	Pathway	associated			26111151

References

Pubmed ID	Year	Title	Citations
14517278	2003	LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.	332
15361868	2004	Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.	303
22820642	2012	Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape.	138
15695821	2005	The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.	133
25814066	2015	Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.	127
14747533	2004	The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes.	124
18227218	2008	PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.	97
15308637	2004	Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection.	91
23175366	2013	Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses.	70
17522209	2007	Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3.	65

Citation

Dessen P

IRF7 (interferon regulatory factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43745/irf7