EIF6 (eukaryotic translation initiation factor 6)

2007-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
CAB,EIF3A,ITGB4BP,b(2)gcn,eIF-6,p27(BBP),p27BBP
FUSION GENES

Other Information

Locus ID:

NCBI: 3692
MIM: 602912
HGNC: 6159
Ensembl: ENSG00000242372

Variants:

dbSNP: 3692
ClinVar: 3692
TCGA: ENSG00000242372
COSMIC: EIF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242372ENST00000374436P56537
ENSG00000242372ENST00000374443P56537
ENSG00000242372ENST00000374450P56537
ENSG00000242372ENST00000415116F8WDS6
ENSG00000242372ENST00000440766F8WD20
ENSG00000242372ENST00000447927A0A0B4J1Y7
ENSG00000242372ENST00000456600B7ZBH1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366512852023Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.1
377763722023Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.0
366512852023Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.1
377763722023Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.0
350247642022Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells.5
358870682022Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.4
350247642022Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells.5
358870682022Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.4
340161422021eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.11
343854472021Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.14
344031012021Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.6
344132982021Somatic genetic rescue of a germline ribosome assembly defect.26
340161422021eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.11
343854472021Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.14
344031012021Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.6

Citation

Dessen P

EIF6 (eukaryotic translation initiation factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43756/tumors-explorer/js/lib/favicon/apple-touch-icon.png