IFI16 (interferon gamma inducible protein 16)

2007-02-01  

Identity

HGNC
LOCATION
1q23.1
LOCUSID
ALIAS
IFNGIP1,PYHIN2
FUSION GENES

Other Information

Locus ID:

NCBI: 3428
MIM: 147586
HGNC: 5395
Ensembl: ENSG00000163565

Variants:

dbSNP: 3428
ClinVar: 3428
TCGA: ENSG00000163565
COSMIC: IFI16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163565ENST00000295809Q16666
ENSG00000163565ENST00000340979A0A0A0MRB1
ENSG00000163565ENST00000359709Q16666
ENSG00000163565ENST00000368131Q16666
ENSG00000163565ENST00000368132Q16666
ENSG00000163565ENST00000426592H3BM18
ENSG00000163565ENST00000447473X6RHM1
ENSG00000163565ENST00000448393Q16666
ENSG00000163565ENST00000474473H3BR88
ENSG00000163565ENST00000566111H3BVE6
ENSG00000163565ENST00000567661H3BR65

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208902852010IFI16 is an innate immune sensor for intracellular DNA.603
215759082011IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.266
230279532012Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.192
243561132014IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV.187
224838012012Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.173
241547272013IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.135
226914962012Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.125
222915952012The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication.104
242377042013Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion.104
234271522013Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes.103

Citation

Dessen P

IFI16 (interferon gamma inducible protein 16)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43784/ifi16