OSBP2 (oxysterol binding protein 2)

2007-02-01  

Identity

HGNC
OSBP2
LOCATION
22q12.2
LOCUSID
23762
ALIAS
HLM,ORP-4,ORP4,OSBPL1,OSBPL4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23762
MIM: 606729
HGNC: 8504
Ensembl: ENSG00000184792

Variants:

dbSNP: 23762
ClinVar: 23762
TCGA: ENSG00000184792
COSMIC: OSBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184792ENST00000332585Q969R2
ENSG00000184792ENST00000401475Q969R2
ENSG00000184792ENST00000403222A0A0A0MSB4
ENSG00000184792ENST00000407373Q6ZN50
ENSG00000184792ENST00000424224C9JS84
ENSG00000184792ENST00000431368H7C428
ENSG00000184792ENST00000433183H7C001
ENSG00000184792ENST00000437268Q969R2
ENSG00000184792ENST00000438716Q969R2
ENSG00000184792ENST00000445781C9J7J0
ENSG00000184792ENST00000446658Q969R2
ENSG00000184792ENST00000452656H7C368
ENSG00000184792ENST00000453621H7C1R2
ENSG00000184792ENST00000454145H7C313
ENSG00000184792ENST00000535268Q969R2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
379039712023Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.2
379039712023Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.2
347979122022ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1.4
347979122022ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1.4
316485752019ORP4L couples IP(3) to ITPR1 in control of endoplasmic reticulum calcium release.9
316485752019ORP4L couples IP(3) to ITPR1 in control of endoplasmic reticulum calcium release.9
299300822018Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding.13
302371642018OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells.9
299300822018Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding.13
302371642018OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells.9
275813632016ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.33
275884682016Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.10
277294672016ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis.11
275813632016ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.33
275884682016Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.10

Citation

Dessen P

OSBP2 (oxysterol binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43794/case-report-explorer/css/js/lib/popper.js