OSBP2 (oxysterol binding protein 2)

2007-02-01  

Identity

HGNC
OSBP2
LOCATION
22q12.2
LOCUSID
23762
ALIAS
HLM,ORP-4,ORP4,OSBPL1,OSBPL4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23762
MIM: 606729
HGNC: 8504
Ensembl: ENSG00000184792

Variants:

dbSNP: 23762
ClinVar: 23762
TCGA: ENSG00000184792
COSMIC: OSBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184792ENST00000332585Q969R2
ENSG00000184792ENST00000401475Q969R2
ENSG00000184792ENST00000403222A0A0A0MSB4
ENSG00000184792ENST00000407373Q6ZN50
ENSG00000184792ENST00000424224C9JS84
ENSG00000184792ENST00000431368H7C428
ENSG00000184792ENST00000433183H7C001
ENSG00000184792ENST00000437268Q969R2
ENSG00000184792ENST00000438716Q969R2
ENSG00000184792ENST00000445781C9J7J0
ENSG00000184792ENST00000446658Q969R2
ENSG00000184792ENST00000452656H7C368
ENSG00000184792ENST00000453621H7C1R2
ENSG00000184792ENST00000454145H7C313
ENSG00000184792ENST00000535268Q969R2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
247426812014Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival.18
173506172007Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization.12
217634552012Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.12
275813632016ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
240694332013Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation.7
129640512003HLM/OSBP2 is expressed in chronic myeloid leukemia.6
275884682016Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.6

Citation

Dessen P

OSBP2 (oxysterol binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43794/osbp2