HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

2007-02-01  

Identity

HGNC
HNRNPA1
LOCATION
12q13.13
LOCUSID
3178
ALIAS
ALS19,ALS20,HNRPA1,HNRPA1L3,IBMPFD3,UP
FUSION GENES
Show Gene Fusions

Article Bibliography

Pubmed IDLast YearTitleAuthors
207163402010Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.Boukakis G et al
178980772007Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.Cammas A et al
127994332003Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.Campillos M et al
127169752003Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance.Chen H et al
294844232018High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.Chen Y et al
179509492008The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element.Cheunim T et al
200108082010HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.David CJ et al
30727061988Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.Dreyfuss G et al
241665032014microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1.Fujiya M et al
271498422016Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.Giannakis M et al
183910212008Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.Goina E et al
175584162007The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a.Guil S et al
207959512010Functional diversity of the hnRNPs: past, present and perspectives.Han SP et al
113134742001Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription.Hay DC et al
253388722015Loss of hnRNPA1 in ALS spinal cord motor neurons with TDP-43-positive inclusions.Honda H et al
120606562002Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor.Hutchison S et al
270665602015Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation.Izumi R et al
172896612007Molecular composition of IMP1 ribonucleoprotein granules.Jønson L et al
240651002013hnRNP A1: the Swiss army knife of gene expression.Jean-Philippe J et al
234554232013Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.Kim HJ et al
279843732017HNRNPA1, a Splicing Regulator, Is an Effective Target Protein for Cervical Cancer Detection: Comparison With Conventional Tumor Markers.Kim YJ et al
109729772000Heterogeneous nuclear ribonucleoproteins as regulators of gene expression through interactions with the human thymidine kinase promoter.Lau JS et al
276942602016Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.Liu Q et al
265815082016Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase.Liu X et al
261513922015CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer.Loh TJ et al
225361162012Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs.Martínez-Salas E et al
154486912004Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.Mendell JT et al
206398842010Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.Michlewski G et al
115859132001Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA.Mili S et al
298725002018Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.Otsuka K et al
13713311992Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.Piñol-Roma S et al
253243062014hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.Roy R et al
229221912012The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.Singh AK et al
221321542011hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.Talukdar I et al
230520362013Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.Teng Y et al
157038182005Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers.Ushigome M et al
156710342005Regulation of gamma-fibrinogen chain expression by heterogeneous nuclear ribonucleoprotein A1.Xia H et al
293674662018Mutations in Hnrnpa1 cause congenital heart defects.Yu Z et al
166037172006hnRNP A1 associates with telomere ends and stimulates telomerase activity.Zhang QS et al
228213762013Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma.Zhou ZJ et al

Other Information

Locus ID:

NCBI: 3178
MIM: 164017
HGNC: 5031
Ensembl: ENSG00000135486

Variants:

dbSNP: 3178
ClinVar: 3178
TCGA: ENSG00000135486
COSMIC: HNRNPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135486ENST00000330752F8W6I7
ENSG00000135486ENST00000340913P09651
ENSG00000135486ENST00000340913A0A024RAZ7
ENSG00000135486ENST00000546500P09651
ENSG00000135486ENST00000546500A0A024RB53
ENSG00000135486ENST00000547276P09651
ENSG00000135486ENST00000547566P09651
ENSG00000135486ENST00000547566A0A024RB53
ENSG00000135486ENST00000547708F8W646
ENSG00000135486ENST00000548688F8VZ49
ENSG00000135486ENST00000550482H0YH80
ENSG00000135486ENST00000550994F8VYN5
ENSG00000135486ENST00000551702F8VTQ5

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378975082024N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation.2
381824292024A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.0
381916212024hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS).2
382680302024MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.0
386854512024circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.1
388671902024Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing.0
378975082024N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation.2
381824292024A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.0
381916212024hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS).2
382680302024MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.0
386854512024circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.1
388671902024Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing.0
364608052023A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA.4
375259102023HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.0
377179392023The mechanism of UP1 binding and unfolding of human telomeric DNA G-quadruplex.0

Citation

Dessen P

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43803/teaching-explorer/gene-fusions-explorer/js/_common.js