PDE4D (phosphodiesterase 4D)

2007-02-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
ACRDYS2,DPDE3,HSPDE4D,PDE43,PDE4DN2,STRK1
FUSION GENES

Other Information

Locus ID:

NCBI: 5144
MIM: 600129
HGNC: 8783
Ensembl: ENSG00000113448

Variants:

dbSNP: 5144
ClinVar: 5144
TCGA: ENSG00000113448
COSMIC: PDE4D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113448ENST00000309641Q08499
ENSG00000113448ENST00000317118Q08499
ENSG00000113448ENST00000340635Q08499
ENSG00000113448ENST00000340635A0A140VJR0
ENSG00000113448ENST00000358923Q08499
ENSG00000113448ENST00000360047Q08499
ENSG00000113448ENST00000405755Q08499
ENSG00000113448ENST00000502484Q08499
ENSG00000113448ENST00000502575Q08499
ENSG00000113448ENST00000503258Q08499
ENSG00000113448ENST00000505453D6RHE0
ENSG00000113448ENST00000505507D6RIG1
ENSG00000113448ENST00000507116Q08499
ENSG00000113448ENST00000509368D6R9L4
ENSG00000113448ENST00000514552D6RAQ0
ENSG00000113448ENST00000515835D6RBB2
ENSG00000113448ENST00000546160A0A087WSZ7
ENSG00000113448ENST00000636120A0A1B0GW84
ENSG00000113448ENST00000638939A0A1W2PQN6

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA151249535diureticsChemicalClinicalAnnotationassociatedPD23778321
PA445086NephrosclerosisDiseaseClinicalAnnotationassociatedPD23778321
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA451201quetiapineChemicalClinicalAnnotationassociatedPD
PA59ARRB1GenePathwayassociated
PA60ARRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
123995922002Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.157
194269552009Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.150
194269552009Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.150
145175402003The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.139
125520972003beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.121
170884262006PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
166420352006An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics.84
160300212005RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62

Citation

Dessen P

PDE4D (phosphodiesterase 4D)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43832/pde4d