ATF6 (activating transcription factor 6)

2007-02-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
ACHM7,ATF6A
FUSION GENES

Other Information

Locus ID:

NCBI: 22926
MIM: 605537
HGNC: 791
Ensembl: ENSG00000118217

Variants:

dbSNP: 22926
ClinVar: 22926
TCGA: ENSG00000118217
COSMIC: ATF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118217ENST00000367942P18850

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
ATF6 (ATF6-alpha) activates chaperonesREACTOMER-HSA-381033
ATF6 (ATF6-alpha) activates chaperone genesREACTOMER-HSA-381183
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186358912008Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis.190
120149892002Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.164
155988912004Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II.156
127138712003Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis.151
118213952002The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi.150
120975572002Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway.121
186503802008ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.109
197237032010Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.103
229175052012Unfolded protein response.91
194202372009ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.85

Citation

Dessen P

ATF6 (activating transcription factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43841/atf6