NOS1 (nitric oxide synthase 1)

2007-02-01 Affiliation

Identity

HGNC

NOS1

LOCATION

12q24.22

LOCUSID

4842

ALIAS

IHPS1,N-NOS,NC-NOS,NOS,bNOS,nNOS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4842
MIM: 163731
HGNC: 7872
Ensembl: ENSG00000089250

Variants:

dbSNP: 4842
ClinVar: 4842
TCGA: ENSG00000089250
COSMIC: NOS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000089250	ENST00000317775	P29475
ENSG00000089250	ENST00000317775	B3VK56
ENSG00000089250	ENST00000338101	P29475
ENSG00000089250	ENST00000344089	C9J5P6
ENSG00000089250	ENST00000618760	P29475

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arginine biosynthesis	KEGG	ko00220
Arginine and proline metabolism	KEGG	ko00330
Calcium signaling pathway	KEGG	ko04020
Long-term depression	KEGG	ko04730
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
Arginine biosynthesis	KEGG	hsa00220
Arginine and proline metabolism	KEGG	hsa00330
Calcium signaling pathway	KEGG	hsa04020
Long-term depression	KEGG	hsa04730
Alzheimer's disease	KEGG	hsa05010
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Metabolic pathways	KEGG	hsa01100
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
ROS, RNS production in phagocytes	REACTOME	R-HSA-1222556
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Nitric oxide stimulates guanylate cyclase	REACTOME	R-HSA-392154
Muscle contraction	REACTOME	R-HSA-397014
Cardiac conduction	REACTOME	R-HSA-5576891
Ion homeostasis	REACTOME	R-HSA-5578775
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated	PD
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD
PA445113	Neutropenia	Disease	ClinicalAnnotation	associated	PD
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated	PD
PA449412	doxorubicin	Chemical	Pathway	associated		21048526
PA449476	epirubicin	Chemical	ClinicalAnnotation	associated	PD
PA449957	ibuprofen	Chemical	Pathway	associated		25502615

References

Pubmed ID	Year	Title	Citations
36682419	2023	nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity.	0
36715280	2023	The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback.	2
38158677	2023	The neuronal nitric oxide synthase expression increases during satellite cell-derived primary myoblasts differentiation.	0
36682419	2023	nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity.	0
36715280	2023	The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback.	2
38158677	2023	The neuronal nitric oxide synthase expression increases during satellite cell-derived primary myoblasts differentiation.	0
35041938	2022	Uncovering associations between mental illness diagnosis, nitric oxide synthase gene variation, and peripheral nitric oxide concentration.	7
35821897	2022	The expanding roles of neuronal nitric oxide synthase (NOS1).	8
36197968	2022	NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice.	9
35041938	2022	Uncovering associations between mental illness diagnosis, nitric oxide synthase gene variation, and peripheral nitric oxide concentration.	7
35821897	2022	The expanding roles of neuronal nitric oxide synthase (NOS1).	8
36197968	2022	NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice.	9
32061134	2021	NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis.	11
33347982	2021	Association of G84A and C276T polymorphism in neuronal nitric oxide synthase (nNOS) gene with herpes simplex encephalitis in eastern Indian population.	0
33434144	2021	Hepatic nNOS impaired hepatic insulin sensitivity through the activation of p38 MAPK.	3

Citation

Dessen P

NOS1 (nitric oxide synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43850/img/gene-fusions/favicon/css/template-card.css