NOS1 (nitric oxide synthase 1)

2007-02-01  

Identity

HGNC
LOCATION
12q24.22
LOCUSID
ALIAS
IHPS1,N-NOS,NC-NOS,NOS,bNOS,nNOS
FUSION GENES

Other Information

Locus ID:

NCBI: 4842
MIM: 163731
HGNC: 7872
Ensembl: ENSG00000089250

Variants:

dbSNP: 4842
ClinVar: 4842
TCGA: ENSG00000089250
COSMIC: NOS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089250ENST00000317775P29475
ENSG00000089250ENST00000317775B3VK56
ENSG00000089250ENST00000338101P29475
ENSG00000089250ENST00000344089C9J5P6
ENSG00000089250ENST00000618760P29475

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Calcium signaling pathwayKEGGko04020
Long-term depressionKEGGko04730
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Calcium signaling pathwayKEGGhsa04020
Long-term depressionKEGGhsa04730
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Metabolic pathwaysKEGGhsa01100
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA445113NeutropeniaDiseaseClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449412doxorubicinChemicalPathwayassociated21048526
PA449476epirubicinChemicalClinicalAnnotationassociatedPD
PA449957ibuprofenChemicalPathwayassociated25502615

References

Pubmed IDYearTitleCitations
189533322008Sarcolemma-localized nNOS is required to maintain activity after mild exercise.138
163809052005Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.131
185916642008Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.122
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
198442072010Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample.87
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
225792902012Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.57
186069552008Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.55
163892742006A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function.52

Citation

Dessen P

NOS1 (nitric oxide synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43850/nos1-(nitric-oxide-synthase-1)