B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8)

2007-02-01  

Identity

HGNC
B3GNT8
LOCATION
19q13.2
LOCUSID
374907
ALIAS
B3GALT7,BGALT15,beta3Gn-T8

Other Information

Locus ID:

NCBI: 374907
MIM: 615357
HGNC: 24139
Ensembl: ENSG00000177191

Variants:

dbSNP: 374907
ClinVar: 374907
TCGA: ENSG00000177191
COSMIC: B3GNT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177191ENST00000321702Q7Z7M8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
329455022020N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.10
329455022020N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.10
293934912018β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells.3
293934912018β3GnT8 regulates oxaliplatin resistance by altering integrin β1 glycosylation in colon cancer cells.3
274599702016Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901.3
274599702016Transcription factor c-jun regulates β3Gn-T8 expression in gastric cancer cell line SGC-7901.3
245731032014β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147.11
247150952014High expression of β3GnT8 is associated with the metastatic potential of human glioma.12
249700532014β3GnT8 plays an important role in CD147 signal transduction as an upstream modulator of MMP production in tumor cells.9
252697612014Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans.10
245731032014β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147.11
247150952014High expression of β3GnT8 is associated with the metastatic potential of human glioma.12
249700532014β3GnT8 plays an important role in CD147 signal transduction as an upstream modulator of MMP production in tumor cells.9
252697612014Knockdown of β3GnT8 reverses 5-fluorouracil resistance in human colorectal cancer cells via inhibition the biosynthesis of polylactosamine-type N-glycans.10
229011752012β3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-β1.5

Citation

Dessen P

B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43857/gene-fusions-explorer/js/css/template-card.css