SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)

2007-02-01  

Identity

HGNC
SH3GLB1
LOCATION
1p22.3
LOCUSID
51100
ALIAS
Bif-1,CGI-61,PPP1R70,dJ612B15.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51100
MIM: 609287
HGNC: 10833
Ensembl: ENSG00000097033

Variants:

dbSNP: 51100
ClinVar: 51100
TCGA: ENSG00000097033
COSMIC: SH3GLB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000097033ENST00000370558Q9Y371
ENSG00000097033ENST00000370558A0A140VJU5
ENSG00000097033ENST00000482504Q9Y371
ENSG00000097033ENST00000535010Q9Y371
ENSG00000097033ENST00000616170A0A087WW40

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
330860352021Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling.3
330860352021Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling.3
324939572020BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growth.6
332022072020Loss of Concurrent Regulation of the Expression of BIF-1, BAX, and Beclin-1 in Primary and Metastatic Melanoma.1
324939572020BIF-1 inhibits both mitochondrial and glycolytic ATP production: its downregulation promotes melanoma growth.6
332022072020Loss of Concurrent Regulation of the Expression of BIF-1, BAX, and Beclin-1 in Primary and Metastatic Melanoma.1
311269722019Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis.18
311269722019Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis.18
271121212016Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.7
275084402016Association of Endophilin B1 with Cytoplasmic Vesicles.8
276094722016Endophilin B1 regulates EGFR endocytic degradation in prostate cancer cell.3
277489422016Bax-interacting factor-1 inhibits cell proliferation and promotes apoptosis in prostate cancer cells.6
271121212016Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.7
275084402016Association of Endophilin B1 with Cytoplasmic Vesicles.8
276094722016Endophilin B1 regulates EGFR endocytic degradation in prostate cancer cell.3

Citation

Dessen P

SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43859/case-report-explorer/js/template.js