IL4R (interleukin 4 receptor)

2007-02-01 Affiliation

Identity

HGNC

IL4R

LOCATION

16p12.1

LOCUSID

3566

ALIAS

CD124,IL-4RA,IL4RA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3566
MIM: 147781
HGNC: 6015
Ensembl: ENSG00000077238

Variants:

dbSNP: 3566
ClinVar: 3566
TCGA: ENSG00000077238
COSMIC: IL4R

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000077238	ENST00000170630	P24394
ENSG00000077238	ENST00000395762	P24394
ENSG00000077238	ENST00000543915	P24394
ENSG00000077238	ENST00000561742	A0A0G2JLA1
ENSG00000077238	ENST00000562142	H3BTD9
ENSG00000077238	ENST00000562968	H3BSE7
ENSG00000077238	ENST00000563002	J9JII2
ENSG00000077238	ENST00000563926	Q5FC08
ENSG00000077238	ENST00000565179	I3L4W9
ENSG00000077238	ENST00000565352	I3L4H7
ENSG00000077238	ENST00000566117	J9JII2
ENSG00000077238	ENST00000566318	H3BRH7
ENSG00000077238	ENST00000568746	Q5FC08
ENSG00000077238	ENST00000628578	Q5FC08

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Hematopoietic cell lineage	KEGG	ko04640
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Hematopoietic cell lineage	KEGG	hsa04640
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164712789	Hepatitis vaccines	Chemical	ClinicalAnnotation	associated	PD	21111021
PA165983754	pitrakinra	Chemical	ClinicalAnnotation	associated	PD
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
19414811	2009	IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients.	118
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
25769611	2015	Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.	91
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
11709756	2002	Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.	78
11709756	2002	Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.	78
19109239	2008	Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.	66
15057902	2004	HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination.	58
12508140	2003	Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms.	51
17179726	2007	Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes.	44

Citation

Dessen P

IL4R (interleukin 4 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43873/il4r