ITCH (itchy E3 ubiquitin protein ligase)

2007-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
ADMFD,AIF4,AIP4,NAPP1
FUSION GENES

Other Information

Locus ID:

NCBI: 83737
MIM: 606409
HGNC: 13890
Ensembl: ENSG00000078747

Variants:

dbSNP: 83737
ClinVar: 83737
TCGA: ENSG00000078747
COSMIC: ITCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078747ENST00000262650Q96J02
ENSG00000078747ENST00000374864Q96J02
ENSG00000078747ENST00000461661A0A1W2PNZ8
ENSG00000078747ENST00000486883A0A1W2PR79
ENSG00000078747ENST00000535650Q96J02
ENSG00000078747ENST00000654846A0A590UIY0
ENSG00000078747ENST00000660337A0A590UK44
ENSG00000078747ENST00000664852A0A590UK95
ENSG00000078747ENST00000665346Q96J02
ENSG00000078747ENST00000665428A0A590UJ55
ENSG00000078747ENST00000665484A0A590UJW8
ENSG00000078747ENST00000670516A0A590UJQ1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
NOD1/2 Signaling PathwayREACTOMER-HSA-168638
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB4REACTOMER-HSA-1236394
Downregulation of ERBB4 signalingREACTOMER-HSA-1253288
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Degradation of GLI1 by the proteasomeREACTOMER-HSA-5610780
Hedgehog 'on' stateREACTOMER-HSA-5632684

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382165582024The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis.2
383426062024Myofibrillogenesis Regulator-1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin-Protein Ligase Itchy Homolog in the Metastasis of Non-Small Cell Lung Cancer.1
383762482024Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.0
385032852024Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.2
385979892024The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.0
382165582024The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis.2
383426062024Myofibrillogenesis Regulator-1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin-Protein Ligase Itchy Homolog in the Metastasis of Non-Small Cell Lung Cancer.1
383762482024Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.0
385032852024Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.2
385979892024The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.0
369298992023The Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers.0
379571382023UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis.0
369298992023The Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers.0
379571382023UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis.0
350917062022Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p/RET axis.7

Citation

Dessen P

ITCH (itchy E3 ubiquitin protein ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43875/tumors-explorer/favicon/js/web-card-gene.js