CD79A (CD79a molecule)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
IGA,MB-1

Other Information

Locus ID:

NCBI: 973
MIM: 112205
HGNC: 1698
Ensembl: ENSG00000105369

Variants:

dbSNP: 973
ClinVar: 973
TCGA: ENSG00000105369
COSMIC: CD79A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105369ENST00000221972P11912
ENSG00000105369ENST00000444740P11912
ENSG00000105369ENST00000597454M0QX61

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
B cell receptor signaling pathwayKEGGko04662
Primary immunodeficiencyKEGGko05340
B cell receptor signaling pathwayKEGGhsa04662
Primary immunodeficiencyKEGGhsa05340
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
CD22 mediated BCR regulationREACTOMER-HSA-5690714

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
213249202011Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.36
126519422003Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).35
173747362007Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
154922622004PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia.15
155911162005Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains.13
195730802009Common genetic variants in candidate genes and risk of familial lymphoid malignancies.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
241468232013Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.11

Citation

Dessen P

CD79A (CD79a molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43891/cd79a